Chemical, Clinical and Immunological Studies on the Products of Human Plasma Fractionation: Xxxii. the Coagulation Defect in Hemophilia. an in Vitro and in Vivo Comparison of Normal and Hemophilic Whole Blood, Plasma and Derived Plasma Protein Fractions.
نویسندگان
چکیده
منابع مشابه
Implementation of Plasma Fractionation in Biological Medicines Production
Context: The major motivation for the preparation of the plasma derived biological medicine was the treatment of casualties from the Second World War. Due to the high expenses for preparation of plasma derived products, achievement of self-sufficiency in human plasma biotechnological industry is an important goal for developing countries.Evidence Acquisition: The complexity of the bloo...
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Introduction Cold plasma is a self-sterilized, painless, and non-contact method in surgeries. These properties allow it to be applied to the living tissues and heat-sensitive parts. The aim of this study was to design a new cold plasma producer device and evaluate the effects of cold argon plasma on decreasing the coagulation time of blood drop in vitro and that of the injured liver blood in vi...
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Background: There are varieties of purification techniques for separation of human plasma proteins such as salting out, ion exchange chromatography, and ethanol fractionation. There are limitations for each method, for example in salting out method, the salt has to be removed in an additional step. Ion exchange chromatography is difficult for scaling up, and plasma fractionation is a time consu...
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Background: Hemophilia B is an X-linked hereditary disorder of blood coagulation system which is caused by factor IX (FIX) deficiency. Factor IX is a plasma glycoprotein that participates in the coagulation process leading to the generation of fibrin. Replacement of factor IX with plasma-derived or recombinant factor IX is the conventional treatment for hemophilia B to raise the factor IX le...
متن کاملThe relation of certain fractions of the plasma globulins to the coagulation defect in hemophilia.
have indicated that normal cell-free human plasma contains some factors which are deficient in hemophilia. There is evidence that by the parenteral administration of derivatives of normal cell-free plasma in hemophilia, the coagulation defect can be modified toward normal. The present communication reviews some of the older work on this subject and presents new evidence accumulated during the p...
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 25 6 شماره
صفحات -
تاریخ انتشار 1946